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Products Images. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development.
T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th T-bet is cooperating with Stat4 signal tranducer and activator of transcription 4 in programming chromatin architecture for Th1 gene expression.
For flow cytometric staining, the suggested use of this reagent is 1. It is recommended that the reagent be titrated for optimal performance for each application.
Additional reported applications for the relevant formats include: immunoprecipitation 2 and immunofluorescence microscopy 3.
Szabo SJ, et al. Cell Science Finotto S, et al. Mullen AC, et al. For research use only. Not for diagnostic use. Not for resale.
By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses.
An isotype control should be used at the same concentration as the antibody of interest. Cy is a trademark of Amersham Biosciences Limited.
This conjugated product is sold under license to the following patents: US Patent Nos. J Interferon Cytokine Res. View reference.
IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue J Exp Med.
T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. T-bet regulates IgG class switching and pathogenic autoantibody production.
Even so, there were "numerous flocks of sheep, goats and horses" and "there was no lack of meat or butter".
Qing dynasty rule in Tibet began with their expedition to the country when they expelled the invading Dzungars.
Amdo came under Qing control in , and eastern Kham was incorporated into neighbouring Chinese provinces in In the Ambans and the majority of the Han Chinese and Manchus living in Lhasa were killed in a riot , and Qing troops arrived quickly and suppressed the rebels in the next year.
Like the preceding Yuan dynasty, the Manchus of the Qing dynasty exerted military and administrative control of the region, while granting it a degree of political autonomy.
The Qing commander publicly executed a number of supporters of the rebels and, as in and , made changes in the political structure and drew up a formal organization plan.
The Qing now restored the Dalai Lama as ruler, leading the governing council called Kashag ,  but elevated the role of Ambans to include more direct involvement in Tibetan internal affairs.
At the same time the Qing took steps to counterbalance the power of the aristocracy by adding officials recruited from the clergy to key posts.
For several decades, peace reigned in Tibet, but in the Qing Qianlong Emperor sent a large Chinese army into Tibet to push the invading Nepalese out.
This prompted yet another Qing reorganization of the Tibetan government, this time through a written plan called the "Twenty-Nine Regulations for Better Government in Tibet".
Qing military garrisons staffed with Qing troops were now also established near the Nepalese border.
In the Sikh Empire invaded and annexed Ladakh , a culturally Tibetan region that was an independent kingdom at the time.
A Qing-Tibetan army repelled the invaders but was in turn defeated when it chased the Sikhs into Ladakh.
The war ended with the signing of the Treaty of Chushul between the Chinese and Sikh empires. As the Qing dynasty weakened, its authority over Tibet also gradually declined, and by the midth century its influence was minuscule.
Qing authority over Tibet had become more symbolic than real by the late 19th century,     although in the s the Tibetans still chose for reasons of their own to emphasize the empire's symbolic authority and make it seem substantial.
His efforts, while largely unsuccessful, established permanent contact between Tibet and the Western world. In , a British expedition to Tibet , spurred in part by a fear that Russia was extending its power into Tibet as part of the Great Game , was launched.
Although the expedition initially set out with the stated purpose of resolving border disputes between Tibet and Sikkim , it quickly turned into a military invasion.
The British expeditionary force, consisting of mostly Indian troops , quickly invaded and captured Lhasa, with the Dalai Lama fleeing to the countryside.
The Qing imperial resident, known as the Amban , publicly repudiated the treaty, while the British government, eager for friendly relations with China, negotiated a new treaty two years later known as the Convention Between Great Britain and China Respecting Tibet.
The British agreed not to annex or interfere in Tibet in return for an indemnity from the Chinese government, while China agreed not to permit any other foreign state to interfere with the territory or internal administration of Tibet.
In , the Qing government sent a military expedition of its own under Zhao Erfeng to establish direct Manchu-Chinese rule and, in an imperial edict, deposed the Dalai Lama, who fled to British India.
Zhao Erfeng defeated the Tibetan military conclusively and expelled the Dalai Lama's forces from the province. His actions were unpopular, and there was much animosity against him for his mistreatment of civilians and disregard for local culture.
After the Xinhai Revolution —12 toppled the Qing dynasty and the last Qing troops were escorted out of Tibet, the new Republic of China apologized for the actions of the Qing and offered to restore the Dalai Lama's title.
During this time, Tibet fought Chinese warlords for control of the ethnically Tibetan areas in Xikang and Qinghai parts of Kham and Amdo along the upper reaches of the Yangtze River.
The Chinese government denounced the agreement as illegal. When in the s and s the regents displayed negligence in affairs, the Kuomintang Government of the Republic of China took advantage of this to expand its reach into the territory.
Emerging with control over most of mainland China after the Chinese Civil War , the People's Republic of China incorporated Tibet in and negotiated the Seventeen Point Agreement with the newly enthroned 14th Dalai Lama 's government, affirming the People's Republic of China's sovereignty but granting the area autonomy.
Subsequently, on his journey into exile, the 14th Dalai Lama completely repudiated the agreement, which he has repeated on many occasions.
The Dalai Lama had a strong following as many people from Tibet looked at him not just as their political leader, but as their spiritual leader.
Afterwards, the Central People's Government in Beijing renounced the agreement and began implementation of the halted social and political reforms.
In , General Secretary and reformist Hu Yaobang visited Tibet and ushered in a period of social, political, and economic liberalization.
The government halted reforms and started an anti- separatist campaign. All of modern China, including Tibet, is considered a part of East Asia.
Tibet has some of the world's tallest mountains, with several of them making the top ten list. Several major rivers have their source in the Tibetan Plateau mostly in present-day Qinghai Province.
Tibet has been called the "Water Tower" of Asia, and China is investing heavily in water projects in Tibet.
The mountain is a holy pilgrimage site for both Hindus and Tibetans. The Hindus consider the mountain to be the abode of Lord Shiva.
The Tibetan name for Mt. Kailash is Khang Rinpoche. Tibet has numerous high-altitude lakes referred to in Tibetan as tso or co.
Western passes receive small amounts of fresh snow each year but remain traversible all year round. Low temperatures are prevalent throughout these western regions, where bleak desolation is unrelieved by any vegetation bigger than a low bush, and where wind sweeps unchecked across vast expanses of arid plain.
The Indian monsoon exerts some influence on eastern Tibet. Northern Tibet is subject to high temperatures in the summer and intense cold in the winter.
Cultural Tibet consists of several regions. These include Amdo A mdo in the northeast, which is administratively part of the provinces of Qinghai, Gansu and Sichuan.
Kham Khams in the southeast encompasses parts of western Sichuan, northern Yunnan , southern Qinghai and the eastern part of the Tibet Autonomous Region.
Tibetan cultural influences extend to the neighboring states of Bhutan , Nepal, regions of India such as Sikkim , Ladakh , Lahaul , and Spiti , Northern Pakistan Baltistan or Balti-yul in addition to designated Tibetan autonomous areas in adjacent Chinese provinces.
There are over settlements in Tibet. Lhasa is Tibet's traditional capital and the capital of Tibet Autonomous Region. Lhasa contains a number of significant temples and monasteries, including Jokhang and Ramoche Temple.
Shigatse is the second largest city in the Tibet AR, west of Lhasa. Gyantse and Qamdo are also amongst the largest. It is governed by a People's Government, led by a Chairman.
In practice, however, the Chairman is subordinate to the branch secretary of the Communist Party of China. As a matter of convention, the Chairman has almost always been an ethnic Tibetan, while the party secretary has always been ethnically non-Tibetan.
The Tibetan economy is dominated by subsistence agriculture. Due to limited arable land, the primary occupation of the Tibetan Plateau is raising livestock, such as sheep , cattle, goats , camels , yaks , dzo , and horses.
The dogs of Tibet are twice the size of those seen in India, with large heads and hairy bodies. They are powerful animals, and are said to be able to kill a tiger.
During the day they are kept chained up, and are let loose at night to guard their masters' house. The main crops grown are barley , wheat, buckwheat , rye , potatoes, and assorted fruits and vegetables.
These include Tibetan hats, jewelry silver and gold , wooden items, clothing, quilts, fabrics, Tibetan rugs and carpets.
Forty percent of the rural cash income in the Tibet Autonomous Region is derived from the harvesting of the fungus Ophiocordyceps sinensis formerly Cordyceps sinensis ; contributing at least 1.
The Qingzang railway linking the Tibet Autonomous Region to Qinghai Province was opened in , but it was controversial. In January , the Chinese government issued a report outlining the discovery of a large mineral deposit under the Tibetan Plateau.
The Chinese government sees this as a way to alleviate the nation's dependence on foreign mineral imports for its growing economy.
However, critics worry that mining these vast resources will harm Tibet's fragile ecosystem and undermine Tibetan culture. On January 15, , China announced the construction of Tibet's first expressway, the Lhasa Airport Expressway , a The project will cost 1.
From January 18—20, , a national conference on Tibet and areas inhabited by Tibetans in Sichuan, Yunnan, Gansu and Qinghai was held in China and a substantial plan to improve development of the areas was announced.
The plan calls for improvement of rural Tibetan income to national standards by and free education for all rural Tibetan children. It is located in the western suburbs of Lhasa, the capital of the Tibet Autonomous Region.
The zone has a planned area of 5. Zone A developed a land area of 2. It is a flat zone, and has the natural conditions for good drainage.
Historically, the population of Tibet consisted of primarily ethnic Tibetans and some other ethnic groups. According to tradition the original ancestors of the Tibetan people, as represented by the six red bands in the Tibetan flag , are: the Se, Mu, Dong, Tong, Dru and Ra.
The proportion of the non-Tibetan population in Tibet is disputed. On the one hand, the Central Tibetan Administration of the Dalai Lama accuses China of actively swamping Tibet with migrants in order to alter Tibet's demographic makeup.
Religion is extremely important to the Tibetans and has a strong influence over all aspects of their lives. Bön is the indigenous religion of Tibet, but has been almost eclipsed by Tibetan Buddhism, a distinctive form of Mahayana and Vajrayana , which was introduced into Tibet from the Sanskrit Buddhist tradition of northern India.
T-bet is widely expressed in hematopoietic cells including stem cells, NK cells, B cells, and T cells. T-bet is critical for the control of microbial pathogens, and knockout animals show multiple physiologic and inflammatory features characteristic of asthma.
T-bet expression is optimally observed after IL stimulation and can be suppressed by addition of the Th2 cytokine IL-4 or neutralization of IL It is recommended that the reagent be titrated for optimal performance for each application.
Additional reported applications for the relevant formats include: immunoprecipitation 2 and immunofluorescence microscopy 3. Szabo SJ, et al. Cell Science Finotto S, et al.
Mullen AC, et al. For research use only. Not for diagnostic use.Kodansha Lion Fish Slots, Inc. Lhasa contains a number of significant temples and monasteries, including Jokhang and Ramoche Temple. The Kingdom of Nanzhao in Yunnan and neighbouring regions remained under Tibetan Domgames from towhen they turned on their Tibetan overlords and helped the Chinese inflict a serious defeat on the Tibetans. Retrieved May 17, The eastern regions of Kham and Amdo often maintained a more decentralized indigenous political structure, being divided Tbet a number of small principalities and tribal groups, while also often falling more directly under Cat Scratch Fever Game rule after the Battle Tbet Chamdo ; most of this area was eventually incorporated into the Chinese provinces of Sichuan and Qinghai. Der T-Box-Transkriptionsfaktor TBX21, auch T-Bet genannt, ist ein Protein, das beim Menschen vom TBXGen kodiert wird. T-bet kontrolliert nicht nur die Produktion von IFN-γ, sondern beeinflusst in einer Art inverser Rückkoppelung auch die Th2 Zellen. Die funktionelle Ausschaltung. T-bet Mouse anti-Human, Mouse, Rat, Clone: eBio39D (39D, D), eBioscience™ 25 μg; Unconjugated Primary Antibodies - Alphabetical Primärantikörper. Jetzt Anti-TBX21 (T-Box 21, T-PET, T-bet, TBET, TBLYM), Artikelnummer: von United States Biological bei Biomol kaufen!